Beauty

Female Pattern Hair Loss- Medicinal Treatment Concepts

The condition can either be treated medically or clinically. We are about to explore the medical side of regaining hair in females. There are many women who use topical minoxidil and oral antiandrogens to regrow some hair, but takes a turn towards clinical treatment mode for stimulating more growth if medications are not effective enough. Hair loss in females is a chronic progressive condition and it takes around 12- 24 months of receiving the initial therapeutic response.  The prevalence increases with age and around 12% of women aged between 20 and 29.  The patterned alopecia is reported at 14.8 years at an average.

The signature feature of FPHL is the progressive transformation of the terminal hair follicles (pigmented, thick and large) to the vellus hair follicles (none pigmented, short and thin) occurs due to the genetic disposition aggravated by the quotient of androgen.  Though, several studies have shown that women have lesser severity of hair loss than men, as a result from a higher level of aromatase lower level of 5 α- reeducates.

Treatment:

  • Minoxidil- This component result in an increased growth rate, lengthened Anagen phase with the shortened Telogen phase and thick diameter of the hair follicle. The improvement seen in the hair counts may not be due to enhanced blood supply, but it increases the conversion of the testosterone to less active androgens and slightly increased reductase activities, helping in the cultured balding scalp human dermal papillae.
  • Finasteride (Reductase Inhibitors) – This is a specific and competitive inhibitor of type II  5α-reductase, the type which most common in hair follicles. It helps to block the intracellular conversion of testosterone to DHT, which enable the hair miniaturization.  Finasteride has no affinity for the androgen receptor  and it is FDA approved daily dosage of 1mg can help you increase the anagen hair count along with reduced progressive hair loss, majorly in men with trails of androgenic alopecia.
  • Dutasteride (Reductase Inhibitors)- this is a more potent reductase inhibitor than Finasteride and is FDA approved for the treatment of symptomatic benign prostactic hypertrophy, not for patterned alopecia though.It has been found that the success rate of the treatment by the use of Dutasteride for FPHL has no observable side effects, which even Finasteride and minoxidil treatment failed to offer.
  • Spironolactone (Antiandrogens) – This FDA approved primary Hyperaldosteronism , hypertension, heart failure, Edematous conditions secondary to liver failure and for reducing hair loss.  Being considered as equivalent to Finasteride, it is proved to be an effective means for a long span of time.  Lower dosage like 50-70 mg may stabilize hair loss, but higher dosage can be considered more beneficial whatsoever.

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